In Silico Screening of Bioactive Compounds from Syzygium cumini L. and Moringa oleifera L. Against SARS-CoV-2 via Tetra Inhibitors

The global pandemic of COVID-19 has caused disastrous consequences for both humans and the economy. purpose this study was to determine potential juwet (Syzygium cumini L.) moringa (Moringa oleifera as inhibitors RBD spike, helicase, Mpro, RdRp activity SARS-CoV-2 with an in-silico approach. Samples were obtained from PubChem RSCB PDB databases. drug similarity analysis determined using Swiss ADME Lipinski rule five. Prediction antivirus probabilities is carried out PASS Online. Molecular screening performed by molecular docking PyRx. Visualization used PyMol Discovery Studio. bioactive compounds best antiviral had lowest affinity bonds target proteins against SARS-CoV-2. Results show that ellagic acid java plum myricetin have antivirals. However, more research required validate results these computational predictions.